Preheat the oven to 350°F (175°C). Position a rack in the center.

In a large bowl, add ground beef, breadcrumbs, chopped onion, minced garlic, egg, salt, pepper, and Italian seasoning. Mix gently until evenly combined.

Shape the mixture into a rectangular loaf about 8–9 inches long and place in a shallow baking dish or loaf pan, seam-side down.

In a small bowl, whisk together ketchup, brown sugar, and Worcestershire sauce until smooth. Spoon the glaze over the meatloaf.

Bake for approximately 1 hour until the internal temperature reaches 160°F (70°C). Tent loosely with foil if the glaze darkens too much.

Remove from the oven and let the meatloaf rest for 10 minutes before slicing.